Theoretically you can but it just makes the whole process more complicated.
Do you see any error messages in verbose mode (-v) ?
Safe mode avoids loading additional extensions but as you installed only the FakeSMC, it must be some Apple extension.
Most probably the freeze is related to the video card. I guess now is the point to make it work.
Don't you have any dedicated video card?
Safe mode is a good start though.
Leave the DSDT aside for now, unless you make any edits that are directly related to the freeze.
Also SMBIOS; you can set it up when you can boot normally.